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On the other hand, evidence indicates that estradiol also plays an important role in differentiating the human brain during early prenatal stages and even after birth ( The disruption of estrogens homeostasis is involved in the development or progression of a series of pathologies, which include several types of cancer (breast, ovary, colorectal, prostate, endometrium), osteoporosis, autoimmune diseases, cardiovascular diseases, obesity and/or insulin resistance (Patel et al., 2018), as well as neurodegenerative diseases (Villa et al., 2016) and mood disorders (Payne, 2003)

A good example of this is understanding why a GP practice is asking to retest your blood for intrinsic factor antibodies (after a diagnosis of PA) or retest your B12 levels while you are on injections because the guideline is clear that this is not necessary

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That excess is filtered by your kidneys and excreted in urine, giving it a distinctive yellow or even almost neon glow