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According to the mechanism study, baicalein could downregulate downstream important glycolytic enzymes (HK2, LDH-A, PDK1) by encouraging the accumulation of intracellular PTEN and inhibiting the activation of the PI3K/Akt signaling, thereby reversing the hypoxia-induced 5-Fu resistance (115)

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However, the possibility that GSH intake from fruit and vegetables might be protective against oral cancer risk could not be distinguished from the more general benefit of consuming raw fruits and vegetables, such as increased ingestion of fiber