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The result is reported in EU/mg on the Certificate of Analysis at cell-culture-reference acceptance limits, allowing the material to be used in sterile adipocyte and chondrocyte assays without LPS-driven confounding signals

therefore, it does not appear to trigger diabetes development or induce glucose intolerance in test models, though further studies are necessary to explore this aspect

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It has FDA approval history for specific pediatric indications and has long been used in certain clinical settings where healthcare providers evaluate growth hormone-related concerns in adults