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Small peptide therapeutics are one of the fastest-growing segments in drug development and manufacturing, driven by the explosive success of GLP-1 receptor agonists and a deep pipeline of candidates across metabolic disease, oncology, and beyond

Over-the-counter antacids or proton pump inhibitors may help, but contact your healthcare provider if symptoms are severe or persistent

In contrast, substitution to an amidated proline instead of an amidated tyrosine in the C-terminus of rAmy is well tolerated, resulting in enhanced affinity and activity at both the CTR and AMYRs, but, in some cases, reduced selectivity between these receptors 18

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