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Longfei et al., 2025

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synergy research IGF-1 elevation occurs gradually and remains within physiological ranges Exogenous HGH release: Sharp spike in serum GH within 1-3 hours of injection Rapid decline as injected protein is metabolized Does not align with natural circadian GH secretion patterns Can produce supraphysiological GH levels depending on dose IGF-1 elevation is dose-dependent and can exceed physiological ranges Side Effect Profile Comparison Published literature documents distinctly different adverse event profiles for these two approaches