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The pLKO.1-scramble vector (#1864, Addgene) was used as a negative control vector and contained a scrambled shRNA (shC)

Clonidine works through the brain and is often reserved for resistant hypertension or withdrawal-related symptoms, while propranolol acts on the heart and is commonly chosen when blood pressure control is needed alongside migraine prevention, anxiety symptoms, or heart conditions

Follow-up and Monitoring: After the therapy session, we will provide post-treatment instructions and schedule any necessary follow-up appointments to monitor your progress and ensure optimal results

They should not be mixed in the same syringe