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As collagen declines, your skin becomes thinner and less resilient, which makes sagging and wrinkles more prominent

In a mouse model with CD68-driven macrophage depletion, reduced macrophages lead to an imbalance in M1/M2 polarization, with a predominance of M2 type, inducing spontaneous PAH accompanied by PASMCs proliferation (Zawia et al., 2021)

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