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With the rise of GLP-1 medications like Ozempic and Wegovy , patients are experiencing incredible results in weight loss but often with one unintended side effect: facial volume loss

The blood lipids (e.g., free fatty acid and triglyceride) and cytokines (e.g., leptin) in mice with global AR knockout (ARKO) or tissue-specific knockout (e.g., liver and skeletal muscle) are significantly increased, and they are prone to suffer from obesity, insulin resistance (IR), and liver fibrosis ( As the metabolic center of energy substrates, mitochondria produce a large amount of adenosine triphosphate (ATP) to meet the energy needs of cells

Ultimately, the conversation around Accutane and weight is a perfect illustration of the difference between a side effect and a therapeutic effect

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