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Fragmented oxidized mtDNA enters the cytosol where it activates NLRP3 inflammasome and generates the production of IL-1, IL-18, and cyclic GMP-AMP synthase-STING, inducing type I interferons and interferon-stimulated genes (Orekhov et al., 2023)

As we age, the production of these proteins decreases, leading to thinner and more fragile under eye skin

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Smoking or other tobacco use status Support for specific tobacco control policies, such as: Prohibiting tobacco retailers near schools Limiting the number of tobacco retailers Prohibiting price discounts and coupon redemption for tobacco products Prohibiting the sale of flavored tobacco products Prohibiting the sale of tobacco products in certain types of establishments (e.g