Seek medical attention if you experience: Severe or persistent nausea and vomiting that prevents you from eating or drinking adequately, as this may lead to dehydration Severe abdominal pain , particularly if it radiates to the back, as this could indicate pancreatitis a rare but serious side effect of GLP-1 receptor agonists [1] [2] Signs of dehydration , such as dark urine, dizziness, dry mouth, or reduced urination Frequent hypoglycaemia (low blood sugar episodes), especially if you are also taking sulphonylureas or insulin Unexplained weight loss that seems excessive or concerning Visual changes or symptoms of diabetic retinopathy worsening, which should be monitored in patients with existing eye complications [1] [2] Allergic reactions , such as rash, itching, swelling, or difficulty breathing Upper right abdominal pain, fever or yellowing of the skin or eyes , which could indicate gallbladder problems Reduced urine output, swelling or confusion , which might suggest acute kidney injury Call 999 immediately if you experience severe chest pain, a severe allergic reaction (anaphylaxis) with breathing difficulties, or severe sudden abdominal pain with vomiting
Sometimes, after several months on a GLP-1, the weight loss slows down
The SUSTAIN-6 trial showed a 26% reduction in major cardiovascular events (heart attack, stroke, or cardiovascular death) compared to placebo
Co-housing could further repress the expression of genes related to bile acid synthesis in GS-R mice, especially the expression of the rate-limiting enzymes of bile acid synthesischolesterol 7-hydroxylase ( Cyp7a1 ), the enzyme responsible for cholic acid synthesis Cyp8b1
