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The FDA proposed a standard requiring all combusted tobacco products to contain less than 0.7mg of nicotine per gram of tobacco

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However, the lack of effect on total nicotine exposure indicates VLNC noncompliance, suggesting that smokers with SMI may respond to a reduced-nicotine standard by substituting alternative forms of nicotine." "Additional doseresponse relationships have been detected on the number of cigarettes smoked per day when low and high nicotine Spectrum cigarettes are available