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Figure 1 summarizes a conceptual overview rather than a single experimental model, developed on the basis of published evidence, with the aim of facilitating the understanding of central and peripheral pathways involved in the GI effects associated with GLP-1 receptor agonists

At the same time, it requires clinicians to balance: -evidence-based practice -clinical intuition -patient-specific context The most effective care often comes from the ability to hold multiple possibilities at once while continuing to move treatment forward

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Even though these otoprotective agents represent a promising new therapeutic strategy for ameliorating, delaying, or even preventing the impact of noise on hearing, finding the ideal therapeutic agent will remain a challenging topic for the future