On the question of whether the benefit in the trial came primarily from weight loss or from other drug effects, Lincoff pointed out that the heart benefits became apparent in the study earlier than the major differences between Wegovy and placebo on weight loss, and he noted that lighter-weight patients to start with experienced the same magnitude of benefit. I think most of us believe that some of this is weight loss, but I think that that oversimplifies a very complex molecule, a complex receptor on multiple tissues, and I dont think its as a simple as that, he said
doi: 10.1111/j.1440-1681.2008.05038.x, 29
Similarly, tryptophan metabolites regulate pulmonary immunity through AhR-dependent IL-22 production and Th17/ILC3 modulation, with microbial imbalance-induced kynurenine/SCFA imbalances exacerbating airway hyperreactivity (Padhi et al., 2024)
(Photo: Triathlete) Across the globe, obesity rates have risen substantially over the past several decades and with that have come significant burdens both to individuals and to health care systems overall
