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Notably, ferroptosis is iron-dependent and differs morphologically and biochemically from other types of RCD

62,63 Critically ill patients have decreased plasma and intracellular levels of chemical antioxidants (free radical scavengers), decreased levels of biological antioxidant chemicals, particularly glutathione (GSH), decreased activity of numerous antioxidant enzymes, and increased levels of pro-oxidants, such as heavy metals

2025 Jan;26(1):5162

This could open new therapeutic strategies, increasing cancer cells' sensitivity to ferroptosis in breast cancer patients who are refractory to other anti-cancer therapies with high expression of CD36