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Free radicals, being highly reactive molecules, can induce oxidative stress and damage vital cellular components like DNA, proteins, and lipids

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The ferroptosis-sensitive cellular transferrin receptor 1 (TFR1) can transports Fe 3+ into cells for reduction to Fe 2+ , which is stored in the intracellular unstable iron pool in the form of an iron storage protein complex consisting of a ferritin light chain polypeptide, and a ferritin heavy chain polypeptide in the presence of divalent metal ion transport protein 1 (DMT1)

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