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This can mechanically irritate the diaphragm via vagus nerve pathways, which is a known trigger for the hiccup reflex

First, the small sample size was secondary to: (a) a national shortage of GLP-1 receptor agonists during the study period [32] with pharmacy availability issues

Dawes, A

Most large studies are funded by large pharmaceutical companies, and there is no incentive for them to continue research of drugs once they are off-patent