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Upon administration, CP amplifies the formation of ROS including hydrogen peroxide, hydroxyl radical, and superoxide anion through stimulation of nicotinamide adenine dinucleotide phosphate oxidase enzymes (Gmez-Sierra et al., 2018)

These changes are likely both direct effects of the medications themselves on the hypothalamus in the brain and ovaries, says Dr

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SURPASS-2 results (40 weeks, type 2 diabetes): Tirzepatide 5 mg: -7.6 kg weight loss, -2.01% HbA1c reduction Tirzepatide 10 mg: -9.3 kg weight loss, -2.24% HbA1c reduction Tirzepatide 15 mg: -11.2 kg weight loss, -2.30% HbA1c reduction Semaglutide 1 mg: -5.7 kg weight loss, -1.86% HbA1c reduction SURMOUNT-5 results (72 weeks, obesity): Tirzepatide demonstrated statistically superior weight loss compared to semaglutide 2.4 mg