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Management Strategy: Management should be individualized and guided by severity and underlying etiology: Correction of the underlying cause Dietary phosphate restriction Phosphate binders: Calcium-based binders (first-line if normocalcemic) Non-calcium binders (e.g., sevelamer, lanthanum) in cases of hypercalcemia or persistent elevation Volume optimization and hydration In CKD, a stepwise, target-driven approach is recommended to control serum phosphate and reduce long-term complications

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