Julien Bezin, Amandine Gouverneur, Marine Pnichon, Clment Mathieu, Renaud Garrel, Dominique Hillaire-Buys, Antoine Pariente, Jean-Luc Faillie
Multi-pathway receptor activation (GHRH + ghrelin pathways)
In cultured human placental cytotrophoblasts and explants from normotensive and preeclamptic pregnancies, luteolin was identified as a potent inhibitor of sFlt-1 release, reducing secretion by more than 95% compared to vehicle controls ( 4.7 Gynecologic malignancies Gynecologic cancers, including ovarian, cervical, and endometrial cancers, account for around 20% of global female cancer burden ( + /ALDH + stem-like ovarian cancer cells, luteolin decreased sphere formation and downregulated stemness genes (SOX2, OCT4, NANOG)
Enhanced Potency: Higher bioavailability and more dramatic results compared to topical application