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I personally experienced, during my years of training in surgery, Halstead modified radical mastectomy for breast cancer, then high dose chemotherapy with autologous bone marrow transplant for metastatic breast cancer. James previously served as chief quality officer and executive director at the Institute for Healthcare Delivery Research at Intermountain Healthcare

Here's when "moderation" goes wrong

The NIH factsheet explains that no tolerable upper intake level has been set for B12, because it has a low potential for toxicity in healthy people