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Compared to patients treated with antidiabetic drugs (excluding GLP-1 receptor agonists), patients treated only with GLP-1 receptor agonists have been observed to be at increased risk of certain comorbidities, such as (1) cardiovascular disorders (hypotension, syncope), (2) gastrointestinal disorders and pancreatitis, (3) degenerative joint diseases, and (4) nephrolithiasis and interstitial nephritis

Most patients qualify and can begin treatment at their first appointment

2025 also marked the FDA approval of the first oral GLP-1 treatment for weight loss in adults

The Bottom Line CrazyLeaf SMGT-GLP-1 Nano Microneedle Patch is not a clinically tested, doctor-endorsed, or FDA-approved treatment for weight loss or blood sugar regulation