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The diabetic environment often results in impaired wound healing processes for DFU, mainly attributed to excess oxidative stimulation, prolonged inflammation, dysfunction of immune cells, delayed reinnervation, and reduced angiogenesis at the wound site [113, 114]

Antimicrobial and regenerative effects of placental multipotent mesenchymal stromal cell secretome-based chitosan gel on infected burns in rats

MT-1 and 2 have ubiquitous tissue distribution particularly in liver, pancreas, intestine, and kidney, whereas MT-3 is found in brain and MT-4 in skin [177]

Burns often delay vessel regrowth because of the sealing heat effect, so this discovery could lead to better treatments in burn care and faster overall mending