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2 Methods 2.1 Literature search PubMed, Web of Science, China National Knowledge Infrastructure (CNKI) were searched, using keywords such as Chronic obstructive pulmonary disease, Mitochondrial dysfunction, Mitochondrial quality control, Mitophagy, Mitochondrial dynamics, Mitochondrial biogenesis, Therapeutic strategies to retrieve studies in ameliorating COPD by targeting mitochondria

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Marys Hospital and Bucheon St Marys Hospital among cohort hospitals because their medical charts related to the development of pneumonia were available for review