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One experimental study in rats showed a gradual decrease in blood pressure following low-salt diet, which was prevented by UA supplementation

Research found that a decreased network response to stimulation in both excitatory and inhibitory circuits of the sensory cortex of Nlgn4 knock-out animals as compared to wild-type controls, and a decreased excitation-inhibition ratio, suggesting that Nlgn4 is involved in the regulation of excitatory and inhibitory circuits and contributes to a balanced circuit response to stimulation (88).Another study reports, Nlgn4 knockout disrupts GABAergic synaptic transmission and oscillatory activity in the hippocampus and causes deficits in social interaction

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however, more studies are needed to confirm the usefulness of ebselen in human subjects