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Nicotine Lozenge Side Effects Side effects that are commonly associated with nicotine lozenge therapy include: Heartburn Hiccups Indigestion Nausea Sore throatIf you experience any of the following side effects, stop using the nicotine lozenge and contact your doctor immediately: Irregular heartbeat or heart palpitations Mouth sores Severe throat irritation Symptoms of nicotine overdose, may include dizziness, vomiting, confusion, blurred vision, and feeling weak Symptoms of an allergic reaction Continuing to smoke while using nicotine lozenges or using more lozenges than recommended could result in serious side effects