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Interestingly, combined treatment was enriched for terms related to tissue development and differentiation (including pharyngeal system development Appendix Table S4), confirming the possible change from basal cell-like to more differentiated epithelial cell phenotype

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The lysine side-chain amino group is not directly involved in copper coordination but contributes to the overall charge and solubility of the complex

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About the Compound GHK-Cu is the copper(II) chelate complex of the human tripeptide glycyl-L-histidyl-L-lysine (Gly-His-Lys)

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The gene SORBS3 has also been implicated in regulating ECM stiffness [74]

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