Phase 2 trial results (48 weeks, adults with obesity): 1 mg dose: 7.2% body weight loss 4 mg dose: 12.9% body weight loss 8 mg dose: 17.3% body weight loss 12 mg dose: 24.2% body weight loss Placebo: 1.6% body weight loss Phase 3 TRIUMPH-4 results: 9 mg dose: 20.0% body weight loss (22.9 kg / 50.5 lbs) 12 mg dose: 23.7% body weight loss (27.2 kg / 60.0 lbs) Placebo: 4.6% body weight loss In a separate phase 3 analysis, retatrutide at the highest dose achieved up to 28.7% weight loss
Muscle atrophy and sports medicine research&Wound healing and tissue engineering Indications: muscular dystrophy, AIDS related muscle consumption, muscle atrophy caused by long-term bed rest.Experimental Design:Animal model: Rats were subcutaneously injected with 0.1-0.3 mg/kg IGF-1 LR3, three times a week for 12 weeks, and the results showed a 15-20% increase in muscle strength.Cell experiment: In the myotube culture system, IGF 1 LR3 1mg can induce upregulation of myosin heavy chain (MyHC) expression and promote muscle fiber type transformation
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