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International patients who are interested in retatrutide may want to: Check ClinicalTrials.gov for trial sites outside the United States Discuss currently available GLP-1 drugs with their healthcare provider Monitor this page and the retatrutide FDA approval timeline 20262028 for updates on international regulatory filings Frequently Asked Questions Can I buy retatrutide now

Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Supplemental Figures 9-10, Supplemental Table 2)

Across the SURPASS 1-5 trials involving over 6,000 participants, the incidence of adjudicated pancreatitis was low and comparable to control groups